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Monogenic cholestatic diseases recently identified illustrate the key role of membrane transporters in biliary function.
Thus, storage/concentration of biliary constituents is not a requirement for normal biliary function.
RSIs of major abdominal organs reflected underlying biliary function.
Epithelial-derived cytokines and chemokines also may alter biliary function leading to cholestasis.
Other extracellular agonists that influence biliary function include neuropeptides [ 2, 3], ATP [ 4, 5], and bile salts [ 6].
This is due to the fact that the primary involvement of the disease is biliary, and transaminase values are related to hepatocyte injury rather than to biliary function.
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These findings all demonstrate that bile acids influence biliary functions which can, in turn, regulate the cholangiocyte response during pathological events.
Biochemical analyses of the renal and hepato-biliary function following oral administration of up to 3000 mg/kg body weight of the crude extracts of the plant were also found to be haematologically safe and did not show any signs of nephrotoxicity and hepatotoxicity in rats, as confirmed by histopathological examination [ 43].
In this study, we aimed to compare the long-term outcomes after ES with those after endoscopic papillary balloon dilation (EPBD) because the latter procedure is expected to preserve biliary sphincter function better than ES.
However, biliary sphincter function is impaired after the treatment, and this may influence the long-term outcomes.
Biliary epithelial function is partially under the control of secretin and vasoactive intestinal peptide [ 1].
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