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The available features of the manufacturing equipment for bilayer tablet production are also described indicating the different strategies for sensing and controls offered by bilayer tablet press manufacturers.
A section is also devoted to bilayer tablet characterization that present additional complexities associated with interfaces between layers.
A bilayer tablet, which consisted of telmisartan and amlodipine besylate, was formulated based on a Quality by Design (QbD) approach.
Therefore, the bilayer tablet that consisted of telmisartan and amlodipine besylate could be produced using a more economical and simpler method than that used to produce Twynsta®.
Several aspects relevant to bilayer tablet manufacturing are addressed including material properties, lubrication, layer ordering, layer thickness, layer weight control, as well as first and final compression forces.
Finally, a roadmap for bilayer tablet manufacturing is advanced as a guideline to formulation design and selection of process parameters and equipment.
Similar(36)
The aim of the present study was a detailed investigation of the relationships between the surface characteristics and deformation properties of tableting materials and the tendency of bilayer tablets to undergo lamination.
Hence, we prepared bilayer tablets having combined loading and maintenance doses using QbD approach.
To test the interfacial strength of the bilayer tablets a new flexural test was proposed.
Acceptable interfacial strength of bilayer tablets was achieved and tablets could be coated without the need for hydroalcoholic solutions.
The effect of the elasticity of various pharmaceutical materials on the interfacial adhesion in bilayer tablets was investigated.
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