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But the biggest use of tobacco was found in low-income countries.
Silk Road is probably the biggest use of the currency, followed by an unregulated online gambling site known as Satoshidice.
The November crackdown was the biggest use of force against protesters in Burma since Thein Sein's reformist government took office in March 2011.
Today, the biggest use of drones is by the military and the Central Intelligence Agency, which operate hundreds of them around the world.
This is the biggest use of "directed assignments" since the Vietnam War, and it represents a long-overdue response to complaints that diplomats aren't pulling their weight in Iraq and Afghanistan.
Until then, the biggest use of genomics is likely to be in drugs discovery.Big pharmaceutical companies have watched their innovation pipelines dry up in recent years, but rapid advances in genomics now promise to change that.
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One of the biggest uses of the green belt, around London at least, is grazing horses.
Nasa, for instance, makes no attempt to recycle the helium used to clean is rocket fuel tanks, one of the single biggest uses of the gas.
This was one of the biggest uses of LEDs ever, and set a precedent of how the technology can push the boarders of entertainment and spectacle. .
Supporters of artificial turf point out that it doesn't need watering and eliminates one of the biggest uses of water in a community.
The other big use of data is for personalized offers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com