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In some sense, the final option would be the biggest setback for reform.
Perhaps the biggest setback for low-income New Yorkers isn't a cut at all, at least not technically.
The biggest setback for the ANC was the loss of the Western Cape, where it won only 31.6%, against 46% in 2004, marking the first time the ruling party has been ousted from provincial government at the polls.
The government is expected to appeal, but the ruling could prove to be the biggest setback for the pesticides industry in this country since the so-called "green revolution" in agriculture began over half a century ago.
Had the law stood, it could have been the biggest setback for voting rights in North Carolina since the Jim Crow era, a brazen attempt by conservatives to upend the rules of democratic engagement and block access to groups most likely to oppose them.
This led to one journalist to suggest to me that it was not just the worst week in office New Labour but 'the biggest setback for the environment movement since Michael Heseltine saw off your anti-nuclear campaigners at Greenham Common'.
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One of the biggest setbacks for queer liberation in the UK this year was the election of a Conservative government, committed to an extensive austerity agenda.
Apple may believe it is best for its business to co-operate with requests from Beijing, but this App Store purge just created one of the biggest setbacks for the free internet in China's history.
Well, folks, a big setback for NASA.
December's airport bombing was a big setback for him.
The loss of Pechiney is a big setback for Alcan.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com