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Discover Ludwig"biggest questions" is a correct and usable phrase in written English.
You can use it when you want to refer to the questions that are most significant or important. For example: "The biggest questions we have to answer are why this happened and what we can do to prevent it from happening again."
Exact(59)
The Giants' biggest questions are on offense.
The biggest questions do not yet have satisfactory answers.
The biggest questions involve injuries to key players.
But the biggest questions are in the lineup.
The biggest questions for next season's offense are: Who will fill the offensive line spots?
One of the biggest questions about the trial is whether Mr. Apotheker will testify in person.
On Tuesday, the biggest questions were as much about the playing conditions as about the team.
For most of the year these are the biggest questions confronting the thirsty New Yorker.
Whether they actually will fight remains one of the biggest questions facing American war planners.
The biggest questions ahead center on the duration and severity of the downturn.
Similar(1)
This is the biggest question.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com