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The biggest disadvantage of using this heuristic is that it is simply too deterministic: the first k−2 neighbors are always fixed (due to fixed edge weights), and in the choice of the (k−1 -th neighbor lies the node's only chance to find a promising clique.
The biggest disadvantage of using the CA19-9 testisg is that sLea structure is neither exclusively expressed for a specific tumour type nor is it expressed in cancer only, but it is expressed at a lower concentration in tissue and serum of healthy individuals of appropriate blood types.
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However, as the MIMO technique is widely used at the relay, the biggest disadvantage of time-domain cancellation is that it cannot take full advantage of spatial-domain resources.
The biggest disadvantage of such a policy is the initial set up costs.
That deals with the biggest disadvantage of solar power, its intermittent nature.
The biggest disadvantage of Mr. Burke was "he had never written a book or a collaboration," Mr. Janklow said.
The biggest disadvantage of active sensors is their power consumption.
What do entrepreneurs think is the biggest disadvantage of working with a female VC?
However, the biggest disadvantage of metal-catalyzed ozonation is the difficulty of the separation of the solid liquid phase.
The biggest disadvantage of this method is poor resolution and zipper artifacts in the horizontal edge regions.
The biggest disadvantage of working with conventional lenders is the length of time it takes to get the loan closed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com