As for the big issues of what should be done to control malaria, our position is clear: Decisions should be based on scientific evidence of what actually works, on local circumstances, and on what proves to be the most cost-effective in terms of reducing disease and preventing human deaths.
Not only was Obama doing the mega-banks' bidding, but he was playing into the conservative framing of the big issue here, of what had caused the 2008 crash and the subsequent soaring federal debt.
The biggest issue of all, surely, is what can be done about the underlying causes for rising inequality in much of the developed world.
But when questions were asked from the floor, the biggest issue of all came into play: what might happen in Scotland after the election of a Conservative government in Westminster?
We cannot lose sight of the bigger issue, which is "What is equitable for Planet Earth?
Will these proposals address the issue of what defines hunting? A. What constitutes hunting is a big debate.
"The president is not making a big issue of gun control," McDonough told CNN. "What's happening in our country, with more than 33,000 deaths" by mass shooting a year, he said, means "this is a big issue".
Internationally, the 2006 Berlin Biennial, Of Mice and Men, curated by a team including artist Maurizio Cattelan, managed to acknowledge both the particular history of Berlin and bigger issues about what it means to make art now.
It has also shaped what people think on the biggest issue of our time.
