First, it is a BiGG knowledge base containing information on the components of human metabolism, mined by extensive literature review [ 4] and accessible online at http://bigg.ucsd.edu[ 18].
They are generated in a bottom-up manner and represent a biochemical, genetic and genomic (BiGG) knowledge bases for target organisms.
STM_v1.0 integrates the novel and common features of the starting MRs into a vetted, well-documented consensus knowledge-base, capturing currently available BiGG knowledge about S. Typhimurium.
GEnome scale Network REconstructions (GENRE) [ 6] represent biochemical, genetic, and genomic (BiGG) knowledge-bases [ 7] for target organisms; and have been developed for expression [ 8, 9], metabolic [ 6, 10], regulatory [ 11], and signaling [ 12, 13] networks.
Here, we describe a community-driven effort, in which more than 20 experts in S. Typhimurium biology and systems biology collaborated to reconcile and expand the S. Typhimurium BiGG knowledge-base.
Metabolic reconstructions (MRs) are common denominators in systems biology and represent biochemical, genetic, and genomic (BiGG) knowledge-bases for target organisms by capturing currently available information in a consistent, structured manner.
An in silico model of a genome-scale metabolic network reconstruction is based upon a biochemically, genetically and genomically (BiGG) structured knowledge base [ 1, 2].
Perhaps Biggs, with his week's worth of Korean knowledge, can explain to us what Samsung means when it's hyping up its 19-inch monitor on its product page.
The content of this knowledge base will be easily accessible through the BiGG database.
A deep approach to learning is characterized by an intention to understand focusing on the concepts applicable to solving problems, relating previous knowledge to new knowledge and it has an internal or intrinsic motivational emphasis (Biggs, 1999).
As a proof-of-concept, we implemented C2CardsHuman (http://www.molgenis.org/c2cards), which combines the knowledge of the following five frequently used human pathway databases: the Biochemically, Genetically and Genomically structured (BiGG) knowledgebase [ 11] (H.
