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The gender differences study got such a big sample size by doing just that.
Its strengths included big sample size, long follow-up and strict blinding.
The method does not need a big sample size, and the results of the method are reliable.
Additionally, a study on the Japanese population used a relatively big sample size (n = 434), which is commendable (Hasegawa et al. 2009).
On a big sample size, we have revealed "blurred" migrainous features in CM patients: the attacks "lose" some of pulsatility and hemicranic character, become almost daily, less intense, but more incapacitating and the patient's suffering is more pronounced.
Selection bias should also be limited given the random sampling procedure and the relatively big sample size.
Similar(36)
There are still some remaining challenges for the usage of WES in large-scale case control studies, in particular the high sequencing price combined with the need for big sample sizes.
Motivation: Very large studies are required to provide sufficiently big sample sizes for adequately powered association analyses.
The big sample sizes and a responder-rate above 70% among patients give adequate statistical power to the performed analyses.
Above all, if the effect is small, it may be impossible to demonstrate without big sample sizes and multiple year studies.
These experiments should be replicated with a bigger sample size.
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