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Exact(58)
The one big problem is that immunotherapy is extremely expensive.
Europe's big problem is that euro-economics isn't working.
The big problem is that Tetra is slow.
The big problem is that Keynote lacks a "paste" control, which is a pretty big oversight.
The other big problem is that goofy jerkoff, Jar Jar Binks.
A big problem is that pavement is a shared space, and a limited resource.
One big problem is that metal in hunks or coils or machinery in pieces is generic and hard to track.
A big problem is that, initially, the handsets running Microsoft's software, made by companies like HTC and Samsung, were unexceptional.
The big problem is that rules are established manually before any activity is assessed.
Similar(2)
A very, very big problem... is that somehow, someway Hispanic was eliminated as a race.
"KPN's big problem is that it has basically underinvested in its own business," Mr. Draper said.
More suggestions(15)
bigger problem is that
greater problem is that
greatest problem is that
biggest problem is that
larger problem is that
big takeaway is that
big discovery is that
big tent is that
big difference is that
big picture is that
big surprise is that
big plus is that
big mistake is that
big regret is that
big danger is that
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com