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"A big outcome would be for us to be able to point to broad support for one of the options emerging quite clearly as the preferred way forward.
He told me that he learned more in that failure than he could have in any big outcome.
The latest example of a big outcome IPO is Rubius Therapeutics, which develops drugs based on genetically engineered red blood cells.
We see great entrepreneurs building on prior successes, joined by a fresh influx of talented founders seeking their first big outcome.
"When I was chief scientific advisor, it was my responsibility to worry about a big outcome with a low probability.
Then, after years of anticipation, the big outcome in Copenhagen was that President Obama got China to shrug ambivalently at a scrap of paper with no targets, proving that twenty years of UN talks have resulted in basically nothing.
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"Leaderless things don't produce big outcomes".
I think that leads to better big outcomes in the end".
VR hasn't produced any big outcomes for Rothenberg, either — yet.
Acquisitions, while comparatively slow for both tech and life science startups last year, also delivered some big outcomes for pharma and healthcare companies.
"The entrepreneurs and their ambition are at a level where we feel very, very comfortable with these companies trying to build very big outcomes, and historically, as you know, because you've been covering the space for a very long time, that hasn't always been the case in the U.K. and Europe," says Saul Klein.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com