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There are big obstacles in the way of a further great leap forward towards European integration.
But ISIS comes up against big obstacles in Syria, as it has done in Iraq.
Health campaigns have faced big obstacles in efforts to change sexual practices (a billboard in Guyana used to advise men to "wear a fresh condom every time").
And they have not reciprocated his show of goodwill.Indeed, there are big obstacles in the way of serious talks—let alone of a negotiated settlement.
However, their slow trap-limited diffusion process and short effective diffusion length of electrons are big obstacles in making more efficient cells.
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There is just one big obstacle in their way: Deborah J. Glick.
Janell Siegfried, a spokeswoman for Honeywell, did note that the sprinkler system idea had faced a big obstacle in that fire-code regulations were very strict and difficult to work around.
A big obstacle in your search is the chaos in the ticker symbols.
However, high cost of reactor which can tolerate high pressure conditions is a big obstacle in its application on large scale (Agbor et al. 2011).
However, Bangle acknowledges one big obstacle in making cars with such distinctly turned angles; as with true sculpture, light and shadow plays better in some colors than others.
But even when a woman successfully leaps over all of these interview hurdles, there's another big obstacle in her path: the pay package.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com