"big limitation" is correct and usable in written English.
You can use this phrase when referring to a significant restriction, obstacle, or disadvantage. For example, "The lack of funding was a big limitation for our research project."
This is called recall bias and is a big limitation of such studies.
"I tell young physicians who are starting out here that the big limitation is imagination," said Dr. Martin Raber, an oncologist — and a cancer patient himself — at Anderson.
But, as a strategy for managing carbon emissions, these recovering forests have one big limitation: the planet simply does not have room for many more of them.
"The big limitation on all of this, when we're talking about treating the forest, is economics," said Mr. Knopp, the Forest Service supervisor.
"Not having natural sunlight is a big limitation when you want to do plant biology," said Kristina Yu, director of the Exploratorium's living systems department.
With smaller boats, the big limitation is that most people want to use the boat on the weekend, not on a Tuesday afternoon when it is free.
Even if big limitations on asbestos lawsuits are not passed, businesses in general will gain from a more conservative federal judiciary, he said.
While the study is interesting, Dr. Goldstein said, it has some "big limitations," in that it is based on a very small number of patients and they were not compared with a control group.
The production world right now is dealing with two big limitations.
The iPhone still has big limitations that make it less useful for business users, particularly battery life.
"I have big limitations of my arm which don't allow me to test in single-seaters," Kubica said.
