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Lifestyle, inactivity, drugs and alcohol can eventually harm your metabolism, but dieting incorrectly and yo-yo dieting are big culprits, too.
Insurance company profits and the rising cost of preventable diseases like diabetes are big culprits in soaring health care spending, Dr. Langston said.
I think the notion that ethics is a code of conduct or a set of rules or a set of principles is one of the big culprits in the meltdown.
A recent study in the Proceedings of the National Academy of Science reported that global trade in amphibians is one of the big culprits in spreading a fungal disease known as chytrid, responsible for the stunning die-off of amphibians across the world.
The big culprits include excessive online gaming, watching pornography, and e-mail.
Those are the big culprits on our home page as well.
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But the participatory nature of the work is not the big culprit here.
Lack of coordination at every point in the health care system is a big culprit.
"Styrofoam is the big culprit," Mr. Rudd said, along with fast-food packaging and plastic water bottles.
The big culprit: credit card processing fees.
Credit card debt is one big culprit.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com