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"big breakthrough" is a correct and usable phrase in written English.
It can be used to describe a significant or important development or discovery in a particular field or situation. Example: The scientist's research led to a big breakthrough in the field of renewable energy.
Exact(59)
A big breakthrough.
What was your big breakthrough?
That is a big breakthrough.
The big breakthrough.
The big breakthrough would be in workflow.
Big breakthrough for South Africa.
Working with Murray proved Smith's big breakthrough.
His big breakthrough was the Munich Olympics.
What was your big breakthrough moment?
It's a big breakthrough for him.
Only quotas will bring the big breakthrough.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com