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The phrase "big brain" is correct and can be used in written English.
It is often used to describe someone who is very intelligent and knowledgeable. Example sentence: His big brain enabled him to come up with the solution to the problem quickly.
Exact(60)
It is art with a big brain.
"He had a big brain," Clinton said.
"He's a big brain," Gamba said.
Dr. Ridley argues that it wasn't our big brain, because Neanderthals had a big brain, too.
The big brain story may have begun in the trees.
She was gifted with a big brain and a bigger heart.
What a big brain we have for all the small talk we make.
Mr. Boies, as you surely have noticed by now, I am the Big Brain here.
I am a man with big strong arms and a great big brain.
"It's not like a big brain science kind of thing," he says.
I have a big heart, but I have a big brain, too".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com