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Figure 7 illustrates the bidirectional translation of BMS-911543's ADME information based on PBPK modeling.
As bridges between clinical researches and genomic researches, these associations would be helpful to accelerate the bidirectional translation between these two fields.
8 To investigate the mechanism of dose-dependent and time-dependent PK nonlinearity for BMS-911543, a PBPK modeling methodology was applied, which enabled the bidirectional translation (forward and reverse translation) of the compound's ADME information.
Because bidirectional translation data are desirable for bilingual research, two lists were created with half of the items being translated from the L2 to the L1, and the other half being translated from L1 to L2.
The methodology of model-guided bidirectional translation of ADME information can serve as a general practice for mechanistic understanding of a new drug's PKs during its early clinical development.
The bidirectional translation and uptake of cultural concepts not only enabled community-specific needs to be identified and addressed in the intervention design, but were also responsible for programme satisfaction and retention.
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The Translational Bioinformatics Conference (TBC) has been one of the most successful multi-disciplinary conferences in the rapidly emerging fields of bioinformatics and clinical genomics for their bidirectional translations.
In conclusion, the results presented here indicate that the bidirectional PBPK model-based translation of ADME information is a useful strategy in general practice for mechanistic understanding of a compound's disposition during early clinical development.
Common themes, including bidirectional transcription and repeat-associated non-ATG (RAN) translation, have recently emerged from expansion disease studies.
Results highlighted the considerable challenges associated with the translation of at-sensor radiance observations to surface bidirectional reflectances in dryland environments, where issues such as high aerosol loadings and large spatial gradients in surface reflectance from bright desert soils to dark vegetated fields are often present.
Consequently, not only do (GGGGCC exp transcripts form foci and undergo RAN translation, so too may (CCCCGG exp transcripts resulting from bidirectional transcription of the C9ORF72 expanded repeat.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com