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However, low-level expression of autosomal roX genes favors local bidirectional spreading of MSL complex, suggesting that roX RNAs are incorporated into the MSL complex when they are transcribed [ 33].
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Thus, subserous space provides not only avenues through which vital structures come from thorax to abdomen and vice versa but also pathways for bidirectional spread of disease processes [20].
As mentioned above, such a bidirectional spread seems at odds with Braak staging in PD, although does not argue against a prion-like disease mechanism.
In contrast, local genomic features likely influence H3K9me2 enrichment at the boundaries of the domains (spanning ∼9 kb at L5chr2EH and 12 kb at L5chr3EH) that result from the bidirectional spread of heterochromatin from the nucleating L5 element (Wheeler et al. 2009 and Discussion).
On the right side, communication with the base of the caecum and right inferior-lateral termination of the small bowel mesentery provides subperitoneal continuity for bidirectional spread of disease between the female pelvic organs and the retroperitoneal and peritoneal organs of the abdomen.
Because this space potentially communicates with the broad ligament, it provides a pathway for bidirectional disease spread between the abdomen and the pelvis[ 2 4 ].
Once again, this presumably reflects the ability of long-distance, unbiased bidirectional transport to aid cargo spreading [ 17].
The gradient that the free iron could exploit is that of bidirectional facilitated diffusion: iron might be able to "spreading out" in case of accumulation and "coming back" in case of consumption if necessary.
This suggests that the boundary defects we observe in Leo1 Paf1 deficient cells are bidirectional because they prevent both heterochromatin and euchromatin from spreading.
The theory of spreading activation proposes that the activation of a semantic memory node may spread along bidirectional associative links to other related nodes.
Dynein is also needed for efficient spreading of uniformly distributed endogenous RNAs from the perinuclear region, supporting a physiological requirement for the motor complex in bidirectional RNA motion (Bullock et al., 2006).
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