Sentence examples for bidirectional regulations from inspiring English sources

In addition, the bidirectional regulations between HIF-1α and COX-2 forming a positive feedback further promote tumor angiogenesis and tumor growth.

Interestingly, within individual autoregulatory loop, PAX2 and PAX6 self-regulate and show bidirectional regulation on each other but with contrary effect: PAX2 positively regulated PAX6, while PAX6 has inhibitory effect on PAX2.

We propose that bidirectional regulation of HCN channel activation by cyclic nucleotides plays an important role in regulating the set point and threshold of HCN channel activation in neurons.

The BESS is capable of fast bidirectional regulation, and hence can be installed within the PV power plants for PV generation regulation [6, 7].

These results elucidated the bidirectional regulation of nephrin by distinct pathophysiologic substances and may provide molecular bases for explaining how proteinuria is induced under pathologic situations and why some ligands for nuclear receptors have the anti-proteinuric potential.

These observations suggest bidirectional regulation of leukocyte telomere length, and raise the possibility that telomeric aging may be reversed.

Our data suggest that bidirectional regulation of HCN2 gating by cGMP contributes to cellular fine-tuning of HCN channel activity.

In this study, we provide for the first time evidence for a bidirectional regulation of the HCN2 channel gating by cGMP (Fig. 5).

Here we demonstrate for the first time that PKG elicits bidirectional regulation of cardiac KATP channel function, including a predominating stimulatory effect resulting from intracellular signaling, plus a moderate inhibitory effect likely resulting from direct PKG phosphorylation of the channel or some closely associated regulatory proteins.

The bidirectional regulation of cardiac-type KATP channel function by H2O2 (Fig. 6) was reminiscent of the H2O2 effects on neuronal-type KATP channels we have recently demonstrated [25], suggestive of a common mechanism underlying ROS/H2O2 modulation of KATP channels in different tissues.

AR may participate in the bidirectional regulation of CX43.