Including such variation could influence the transmural heterogeneity in AP morphology and duration through the bidirectional coupling between voltage and calcium within the cell.
First, we change the bidirectional coupling between experiment and computer simulation to a unidirectional coupling and stabilise the experiment with a feedback loop.
The bidirectional coupling between membrane potential and cytoplasmic (mathrm{Ca}^{2+}) concentration, as well as the high-dimensionality of model (1a)–(1g), are complications not present in previous related analyses [15, 23].
In this study, the method described in [21, 22] is used for bidirectional coupling between OMNeT++/MiXiM and SUMO, where the two simulators communicate with each other through a traffic control interface (TraCI) by transmitting TCP messages.
While the bidirectional coupling between V and (mathrm{Ca}_{mathrm{i}}) as well as more detailed (mathrm{Ca}^{2+}) dynamics make the implementation of the decomposition method more difficult than in past work on similar models, fast-slow averaging allowed us to complete the analysis.
However, in all modeling studies reported so far numerous simplifications were made in terms of representing biophysical details of cellular function and its heterogeneity, gross anatomy and tissue microstructure, as well as the bidirectional coupling between electrophysiology (EP) and tissue distension.
Specifically, SH2-CD linker heterogeneity among SFKs influences the bidirectional coupling between their αC helices and regulatory domains.
The SS system features bidirectional coupling between v and (ca_{i}), which is similar to that in the Jasinski model; therefore, we may also be able to explain the mechanisms underlying SS dynamics from the perspective of how the ((v, h)) system is driven by the ((ca_{i}, c_{mathrm{tot}}, l)) system in analogy to our approach for SB solutions in Sect.
