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Many of the effects appear to be due to the release of bidirectional activity of neighboring promoters.
The Drosophila ras2 promoter region exhibits bidirectional activity, as has been demonstrated for the human c-Ha-ras1 and the mouse c-Ki-ras.
It seems probable that PROMPTs transcribed diverging away from the gene (or the main mRNA promoter) could be promoted from the bidirectional activity inherent of promoters.
DNA elements (from cluster 3) with predicated bidirectional activity from P. falciparum were cloned in sense and anti-sense to M-cherry and EGFP, respectively.
Our method is able to capture the bidirectional activity of the genes in the diseases allowing finding genes with greater biological relevance.
Moreover, they display a unique GC skew profile, while the associated coding genes have large first exons, both properties likely reminiscent of their bidirectional activity.
Similar(47)
An unexpected outcome of the FANTOM5 analysis was that CAGE profiling also identified around 40,000 active enhancers in the human genome, based upon their bidirectional promoter activity [ 8].
Both regions exhibited bidirectional promoter activity in the assay.
However, the bidirectional promoter activity of this element may disturb expression of neighboring genes.
Notably, not all CGI promoter regions show bidirectional promoter activity.
RNA could be transcribed outwards using the inherent bidirectional transcriptional activity of Pol II promoters.
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