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Similarly, during death receptor-mediated apoptosis caspase-8 cleaves the Bcl-2 member Bid generating an active C-terminal fragment that induces the proapoptotic release of cytochrome c from mitochondria.
To achieve triggering of the mitochondrial pathway, caspase-8 cleaves the pro-apoptotic BH3-only protein Bid, generating truncated Bid.
Caspase-8 directly activates effector caspase-3 to induce apoptosis through the type I pathway or cleaves the BH3-only protein Bid, generating tBid.
Caspase‐8 cleaves Bid, generating tBid, which is then translocated to the mitochondria to promote the release of cytochrome c (Dirks & Leeuwenburgh, 2005).
In some cases, the death receptor and mitochondrial pathways are interconnected via the activation of the Bcl-2-family member protein, Bid [ 7, 8], where caspase-8 cleaves Bid, generating activated tBid which triggers the release of cytochrome c [ 9].
In this case caspase 8 among other things cleaves a BH3 only protein BID generating a truncated fragment known as truncated BID (tBID) that can permeabilize the mitochondrion resulting in MOMP [ 12].
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His Senate bid generated a torrent of media attention and excited voters in a party desperate for fresh political faces.
Of note, the N-terminal fragment of Bid generated by caspase cleavage can be also degraded in an ubiquitylation-dependent manner.
In the real Iran market in which the pricing mechanism is pay-as-bid, generating companies tend to propose their prices more than their MCs and near to the price cap to achieve more profit.
More important for the auction house, online bidding generated a hefty 33percentt of the customers that were added to its database that year, according to Christie's.
In a takeover battle in 1999 that pitted Comcast against AT&T for control of the MediaOne Group, the bidding generated $345 million in fees for investment bankers, lawyers and accountants.
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