Sentence examples for bicarbonate activation of the from inspiring English sources
Bicarbonate activation of the Arg175Glu mutant was non-saturable (linear vs. hyperbolic), indicating a lack of a specific binding site (Fig. 4).
The Asc activation profile of the Phe300Gln mutant is similar to the bicarbonate activation profile of the Lys158Leu mutant (Figs 8 and 9).
The Lys158Leu mutant had a 5-fold higher ACC Km and a normal Asc Ka and bicarbonate activation was non-saturable while activity was 50-fold lower than that of the native ACCO.
In an elegant review, Visconti summarized that the early stage of capacitation mainly comprises the bicarbonate-mediated activation of sperm motility, whereas the late stages include intracellular alkalinization, increase in protein tyrosine phosphorylation, and preparation for the acrosomal reaction [ 63].
This was most often the case when assaying mutants with bicarbonate varied where bicarbonate activation was linear rather than hyperbolic.
Lubiprostone has been reported to stimulate bicarbonate secretion which was suggested to be through activation of the EP4 PGE2 receptor [ 20] and activation of Cl- secretion was blocked by an EP4 receptor antagonist [ 23].
In addition, mineralocorticoids such as aldosterone stimulate sodium reabsorption in the collecting duct through activation of the ENaC and therefore allow bicarbonate recovery and chloride loss in urine.
Mineralocorticoids such as aldosterone stimulate sodium reabsorption in the collecting duct through activation of the ENaC and therefore allow bicarbonate recovery and chloride waste in urine [ 35].
Activation of the GC-C receptor promotes intracellular synthesis of cGMP and subsequent activation of CFTR, resulting in chloride and bicarbonate secretion as well as paracellular movement of sodium and water into the intestinal lumen.
