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Finally, limits and biases of this study should be mentioned.
We acknowledge the limitations and potential biases of this study due to the retrospective collection of data and the relative disparity of the treatment types.
Other potential biases of this study should be limited, given the almost complete response rate, the administration of a standard questionnaire under similar conditions, and the same catchment area for cases and controls.
Other potential biases of this study should be limited, given the almost complete response rate, the similar catchment area for cases and controls and the administration of a standard questionnaire under similar conditions.
With this relatively high cutoff we tried to reduce the impact of potential biases of this study linked to the observation, confirmed in our series (Table 3), that subjects with low haemoglobin levels have low quality of life scores when compared to subjects with greater levels (Holzner et al, 2002), and this condition might not permit aggressive oncological approaches.
Similar(55)
The outcome assessment was not blinded from the procedures, and it might include potential bias of this study.
A possible bias of this study is that 50.7% of patients were on additional prophylactic medication (most often amitriptyline or divalproex).
The bias of this study was unsuccessfully treated patients who presented to our clinic, thus successfully treated sinus headache cases could have been overlooked.
A clear bias of this study could have been the longer time elapsed from the baseline cross-sectional until the first malarial episode in children without intestinal helminthes, subjected therefore to other determinants of anemia.
Considering the low number of SLNB performed in our hospital and the low false-negative rate (<5%), we did not think SLNB would cause obvious bias of this study.
The measures of perceptual bias of this study fall within the range reported in Fuentes and Bastian [31] (accuracy in the passive elbow angle task was estimated from Figure 3B and converted to bias in mm at the hand, resulting in a range from −72.3 mm to 56.9 mm).
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