But this would permit again the problem of biased sequences; a string of all heads tossed by a two-headed coin could then be random, which it is not).
But the generalisation invoked here does give some succour to von Mises, for a robust notion of randomness for biased sequences is a key ingredient of his form of frequentism.
However, we find that by deferring the cluster coordinate mapping until the sequencing cycles that immediately follow the initially biased sequence, a maximal number of clusters can be identified.
Initial studies based on microbial genome sequencing revealed an almost bias free sequencing of even very high GC content regions (data not shown).
Finally, we note that to accurately compare genomic regions enriched for spreading histone modifications such as H3K9me3 and H3K36me3, we developed a modified peak calling program that takes into account duplicated regions of the genome, biases in sequencing of certain regions, and the jagged profile of regions enriched for histone modifications.
Finally, we noted a bias toward sequencing of male individuals.
Assessing risk of bias: sequence generation; allocation concealment; blinding of participants and personnel; blinding of outcome assessment; incomplete outcome data; selective outcome reporting; other potential sources of bias.
It should be borne in mind that the design of the probes on the array was biased toward known sequences of Gram negative organisms of human health significance.
We will evaluate the following domains for risk of bias: sequence generation, allocation sequence concealment, blinding of participants and personnel and outcome assessors, incomplete outcome data, selective outcome reporting and other sources of bias.
Our results show that these mSDs are never retained in orthologous genes (data not shown), indicating the possibility of biased selection of mSD sequences of orthologous genes.
