Sentence examples for biased selectivity from inspiring English sources

This means that increasing levels of FT predicts later increases in behavioral approach but not avoidance tendencies by organizing the striatum for biased selectivity for positive over negatively valenced information.

The biased selectivity did not depend on which stimulation period was chosen, either, as we obtained almost identical results (data not shown) when a sliding full-cycle time window was used, which was shifted gradually within the 1.5 cycles, after hemodynamic delay was adjusted.

Less precise estimates are those that are more likely to be biased on selectivity grounds.

This latter effect leads to agonist "functional selectivity" (also called ligand-directed receptor trafficking, stimulus trafficking, biased agonism, biased signalling), and agonist intervention with functional selectivity may improve the therapy.

The first serotonin crystal structures not only provide the first evidence of serotonin receptor topography but also provide mechanistic explanations into functional selectivity or biased agonism.

Increasing evidence demonstrates that different opioids, while acting μ opioid receptors, can activate distinct downstream responses, a phenomenon termed functional selectivity or biased agonism.

Our functional GPCR models are able to rationalize subtype selectivity and biased signaling.

Antagonism of these receptors, however, may only partially explain the therapeutic benefits of β-blockers and angiotensin receptor blockers given the emerging concept of functional selectivity or biased agonism.

40– 42 Concepts such as functional selectivity and biased ligands have emerged and will most likely influence future pharmacological assay design 43, 44 as well as drug discovery efforts directed toward these targets.

Of note is also the concept of so called biased agonism or functional selectivity at GPCRs, which implies that different ligands can activate distinct signalling pathways and differentially regulate desensitization, internalization, down-regulation and dimerization processes [ 108].

Interestingly, PAK1mediated Akt activation exhibits isoform selectivity, affecting Akt1 responses more than Akt2, and in addition biased Akt substrate selection [ 136].