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A nonlinear system model with unknown faults is established based on the separate-bias principle.
Nevertheless the referee is right that this experimental paradigm may be in principle biased by reduced basal transmission and this possibility is now mentioned: "Even though reduced basal transmission might in principle interfere with LTP analysis, these results suggest nevertheless that synaptic plasticity is affected by Aph1BC deletion".
The major drawback of that analysis was that it was based only on bioinformatic evidences and thus was in principle biased by our assumptions on TF and miRNA binding sequences.
Another limitation of the study is that the effects of the CARe training may be biased because several principles of rehabilitation and recovery are already used in regular practice to some extent, which might bias the 'care as usual' condition.
This analysis may in principle be biased by the more rapid evolution in endosymbionts compared to free-living bacteria [ 78].
This approach should in principle be biased towards proteins that are of particular importance for bacterial interactions with the environment.
By definition, UEs extract time windows with a high coincidence count and therefore could in principle be biased to detecting coincidences that occur in close temporal proximity.
The principle biases for the physician who saw him in the clinic were framing, search satisficing and premature diagnostic closure.
The strips are biased using the punch-through principle and AC-coupled via metal strips separated from the strip implant by an insulating oxide/nitride layer.
This principle might have biased our results toward these genotypes.
It is unlikely, therefore, that the formal violation of the double-blind principle may have biased the study outcome.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com