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Local availability of precursor and reduced atoms may also contribute to this biased growth.
Since biased growth cone filopodia extension was blocked by 10 µM CNQX in our experiments, it suggests glutamate mediates the attractive chemotaxic growth cone behaviour that is observed.
By contrast, a pattern similar to wild-type deformation anisotropy was sufficient to explain these morphogenetic processes without spatially biased growth.
In contrast to the SHH case, inhibition of FGF signaling by SU5402 (SU) caused a decrease in the tissue growth rate independently of developmental stage; therefore, the distally biased growth mode observed in earlier stages is determined by FGF signaling from the apical ectodermal ridge.
However, these previous studies may have resulted in biased growth parameter estimates because these samples were not chosen at random and hence violated the assumptions of the method.
The activity of Ran results in biased growth of microtubules towards the DNA, which in turn leads to a relatively high amount of tubulin polymer near chromosomes.
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Furthermore, by combining the resulting deformation map with morphogenetic computer simulations, we evaluated the roles of globally oriented local tissue stretching and spatially biased volume growth through cell proliferation in directional limb bud growth and limb-specific morphology.
In this study, by combining estimated deformation maps and morphogenetic simulations (geometrical simulations without any assumptions about tissue mechanical properties), we showed that globally oriented local tissue stretching, not spatially biased volume growth, is the main determinant of directional limb bud growth and limb-specific shaping.
The associations may be biased by growth dilution and pharmacokinetic changes during pubertal development.
My administration will be a little more biased toward growth.
That will make it harder for councils in overheated areas to turn down developers.The government is right that the planning system is excessively biased against growth: existing property-owners, who control the system through local authorities, have little interest in sanctioning developments which may reduce the value of their houses.
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