Given the importance of the ankyrin repeat-containing latrotoxins in black widow venom, the venom gland biased expression of these transcripts is intriguing, although their links to the action of latrotoxins are speculative at this point.
We detected parent-of-origin (PO) biased expression of 48 genes, an equal number of which were expressed with maternal and paternal biases, respectively.
However, in silico expression analysis shows biased expression of individual domains of the identified retroelements in male plants.
This is especially so for allopolyploids, which can experience (i) changes in methylation [ 31], (ii) disruption of heterochromatin leading to retrotransposon activation [ 28] and (iii) alteration in imprinting and biased expression of homologs [ 32].
To determine whether there is biased expression of TCR Vβ segments in CD4+ cells in sarcoidosis, a panel of 24 antibodies covering approximately 70% of the TCR Vβ repertoire was tested on 15 patients.
Progress toward understanding this epigenetic phenomenon will proceed in parallel with the identification of candidate gene sequence polymorphisms that support allele-specific gene expression assays to address whether or not the ovary, or a specific subset of ovarian follicles, exhibit imprinted or biased expression of candidate GC tumor susceptibility genes.
We also observe tissue biased expression in hundreds of lineage specific genes, which may represent candidates for neofunctionalization and new gene origination.
Given the male-biased expression of this transcript in the accessory gland and its presence in the male ejaculate, we name the gene encoding this transcript ejaculate serine protease – with the protein and gene being abbreviated EJAC-SP and ejac-sp, respectively.
Thus, it is possible that the sex-biased expression of this gene is strain- or condition-dependent.
Thus, the sex-biased expression of this shared genetic substrate must be an integral component of the sexual differentiation of a tissue.
