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Frias-Martinez et al. raised this question in [183], regarding e.g. the socio-economic level that could be biased among mobile phone users compared to the whole population.
As expected, the results are disappointing: the estimator (r_{12,Q}) turns out to be the most biased among the robust estimators considered and it also has larger variance than both (r_{12,COMED}(1)) and (r_{12,B}(1)).
Note that only two genomes were sequenced per taxon, so rates of within-group polymorphism are certainly underestimated but should not be biased among taxa being compared.
This is the most comprehensive analysis of imprinting in Arabidopsis, and we find that most imprinted genes are consistently parentally biased among strains; this is an important conclusion in its own right.
In general, the mitochondrial COI gene sequences in the DNA database are biased among taxa, and this bias was assumed to be the main reason for the occurrence of Hexapoda in our analysis.
It was shown recently that the species specific combinations of three consecutive codons are highly biased among fungal species and even reaching to the complete vanishing of certain combinations [ 27].
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