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Selection bias will be controlled by means of propensity score adjustment.
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Potential data biases will be controlled for by the access and analysis multiple health data sources over a minimum of 6 years.
Non-inclusion or non-termination biases will be controlled for using selection models - including Heckman type models [ 37] - and other approaches to take into account for the drop out process [ 38].
To prevent bias, these potential confounders will be controlled in analyses comparing network-level outcome rates.
We presented a pragmatic design in which the magnitude of potential bias will be assessed and controlled.
55 Similarly, a natural concern with regard to attention bias will be involved for the control group as it is not being seen by anyone or not seen as much by the clinical investigator as the other two groups.
We cannot control for this bias, but at least this bias will be conservative for outcomes such as the antibiotic prescription rate and the duration of antibiotic therapy.
Publication bias will be assessed.
This type of bias cannot be controlled.
Other bias: any other apparent biases will be evaluated.
These biases will be reported when necessary.
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