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The methodological quality (risk of bias) was evaluated using the Cochrane Risk of Bias Tool that addresses the domains of randomisation adequacy, blinding, allocation concealment, whether the intention-to-treat analysis was utilised, and attrition rate.
Risk of bias was evaluated using a tool based on recommendations from the CAMARADES group [1].
Publication bias was evaluated using a funnel plot of a trial's effect size against the standard error.
Risk of bias was evaluated using the PEDro scale, and overall quality of evidence was assessed using the Grades of Research, Assessment, Development and Evaluation (GRADE) approach.
Publication bias was evaluated using Egger's test.
Publication bias was evaluated using Stata V.12.0.
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The upwind bias is evaluated using an estimate of the largest eigenvalue, which in any case is needed for selecting a time step.
Predictive capabilities of the 15% trend alarm regarding the bias were evaluated using Spearman correlation, chi-square test, ROC analysis and Wilcoxon test (IBM SPSS 20).
To determine if misclassification differed statistically significantly across characteristics such as gender, education etc., significant differences in the mean misclassification bias were evaluated using a t-test, or one-way ANOVA where appropriate, for the SLÁN 2007 data.
Publication biases were evaluated using Funnel plots and Egger's tests [ 16].
Methodological quality, including risk of bias of the studies, was evaluated using the PEDro Scale.
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