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An initial small bias to interact with proteins of a similar age could have been amplified by duplication events.
5) The data in Figure 5 is puzzling: Hox d11 is switching domains within the Hox cluster from E8.5 to E10.5, yet it does have the same bias to interact with the telomeric desert as the d4 gene.
Perhaps the authors can either clarify this, or discuss this in the paper: do they think each gene is acting independently, or are there three groups (D1-D8; D9-11, D13)? 5) The data in Figure 5 is puzzling: Hox d11 is switching domains within the Hox cluster from E8.5 to E10.5, yet it does have the same bias to interact with the telomeric desert as the d4 gene.
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Thus, even after correcting for ascertainment bias, we can confirm that HIV tends to interact with proteins that have a high degree.
Three major findings were of particular relevance: Firstly, there was a bias in the way genes interact, with interacting old genes more likely to interact with other old genes; Secondly, interacting new genes are more likely to interact with other new genes; Finally, we observed that new genes interact more cohesively than old genes.
After correcting for ascertainment bias in the literature, we demonstrate a significantly greater propensity for HIV to interact with highly connected and central host proteins.
One hundred nine compounds were selected for functional evaluation, with the selection biased to approximately 75%% of the chosen compounds as not predicted to interact with EGF.
Fluency had no influence on the desire to interact with others of the same race, indicating that this potent cognitive bias is especially consequential in the judgments of out-group members.
Ideally, simulations would allow unconstrained AFPs to migrate from the water phase to interact freely the growing ice-water interface without introducing prior binding orientation bias.
The main focus of the workflow is the selection of complete libraries for unbiased screening, namely screening which is not biased by knowledge of the structure of the biological target or of compounds known to interact with it.
Moreover, such biases can cloud quantitative assessments of whether a set of proteins of interest tend to interact with each other, and are therewith 'physically cohesive'.
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