Our method generalizes this approach, attempting to overcome this problem by using an estimation of sequence probability that requires fewer parameters and can account for bias outside of the initial heptamer.
To test whether the extent of transcript reduction was biased because of the initial mRNA abundance, we classified all yeast genes by their starting mRNA abundance in 10 equal groups (decile classes).
Under-representation of GC-rich regions has been suggested to be a result of bias in the initial PCR steps during library preparation [ 20, 36] and of miscalls originating from the sequencer [ 10].
This simple, yet effective approach can dramatically increase the volume of data returned from libraries with a high degree of bias within the initial bases.
A monastrol washout led to bipolar spindles with few unaligned chromosomes, 74.4% of which were adjacent to old centrosomes, indicating that the bias is independent of the initial centrosome position.
This finding suggests a more general approach for assessing model performance where the point estimates and confidence intervals are more robust to inclusion of additional information, probably because of less bias in the initial estimates from nonindependence in the observations, particularly from excluded exposure information.
Although the high train use adjustment gravity model predicts a slight bias towards coastal fadeouts, it corrects for most of the bias in the initial, unadjusted gravity model predictions and more accurately reflects the observed data.
A potential limitation of the STRIP study is the possible selection bias in the initial recruitment of the subjects: the participating families might have been more interested in health-related issues than the nonparticipants.
Of the 16 participants, seven reported prior use of CT and therefore this could be an influencing factor or bias in the initial use of the nature videos.
To guard against the possibility that functional categories were identified by chance due to the a priori bias in the initial set of profiling molecules, we randomly selected three additional sets of the same size from the same initial profiling molecules, and submitted these random gene lists to IPA.
