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By excluding non-English publications, the potential for publication bias may exist when focusing on the causes of MAEs.
Therefore, indication bias may exist when insulin is used in patients having more comorbidities and using more concomitant drugs that may also affect the risk of breast cancer.
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Additional challenges may exist when integrating these types of data.
To the extent that selection bias may exist, the effect is likely to be small.
However, many sources of bias may exist in a shotgun metagenomics protocol.
Besides an overall bias in the signal intensity, which is corrected for by the simple scaling normalization procedure, additional probe specific bias may exist.
Therefore, selection bias may exist.
Consequently, unexpressed bias may exist.
Consequently, unexpected bias may exist.
Finally, publication bias may exist.
Nonetheless, non-response bias may exist.
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