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Because changes in network composition that are induced by peer recruitment (i.e., increased interaction with peers that is related to the study design) could also introduce bias into the outcome measures in intervention evaluations, it is also necessary to evaluate prospective changes in social network composition among individuals recruited by their peers, but in the absence of an intervention.
Both actions will introduce inadvertent bias into the outcome assessment.
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This large number of excluded patients may have introduced bias into the outcomes, but this is a scenario in an ordinary clinic.
Some of these may introduce bias in the outcome.
Although 50 centres were unable to participate in follow-up, this could not have introduced bias into the assessment of outcome, as randomisation had been stratified by centre.
12 Although 50 centres were unable to participate in the follow-up, this could not have introduced bias into the assessment of outcome, as randomisation had been stratified by the centre.
The following criteria were taken into account to grade the evidence: study limitations (risk of bias for the outcome of interest), consistency of effect, imprecision, indirectness, and publication bias.
This analysis was conducted without bias towards the outcome.
This limits information bias for the outcome recovery.
The primary limitation of this study was the lack of a concurrent control group, which may have introduced bias into the interpretation of study outcomes.
Despite rising concern that conflicts of interest may bias the outcome of clinical trials, the Food and Drug Administration has distressingly limited interest in rooting out the problem.
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