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Veterinarians' focus on specific problems influenced their motivation to collect data and this may have introduced variation and bias into the data.
It became apparent that this introduced a bias into the data, likely related to 'indication bias,' whereby patients 'doing well' would be less likely to start a DMT.
Thus, the effect of any unmeasured differences in oxygen solubility would be (at most) to introduce a small systematic bias into the data.
While this method facilitates the collection of data, questions remain about the level of accuracy, the appropriate ages to which this method should be targeted and the potential for introducing bias into the data collection process[ 15, 16].
Requiring active parental consent procedures may also hinder research by adding a prohibitive cost to research [ 20, 21] and by introducing a potentially significant sample bias into the data [ 17, 22].
Using these metrics the whole genome capture technique is as efficient as the current leukocyte filtration method in removing contaminating human genomic DNA and allowing whole genome analysis of the P. vivax field samples without introducing any bias into the data.
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However the cost of this choice is that it introduces potential recall biases into the data and may reduce the possibility that anger ratings will be related to choice behaviour.
This level of enrichment allows for efficient analysis of the samples by whole genome sequencing and does not introduce any gross biases into the data.
Moreover, these approaches are limited to identifying and studying polymorphisms that are common in the populations and genomic regions that are best represented in public sequence databases, which introduces ascertainment biases into the data.
Several factors may introduce strong biases into the data sets obtained in these studies including (1) differences in proliferation rates of the individual targeted cells, (2) intrinsic difficulties in retrieving certain targeting sequences, and (3) biases in obtaining PCR products from certain templates but not from the others.
Likewise, the existence of a selection bias in the data should be taken into account, because the dependent people analyzed in this study were only those living at home, while all others were excluded.
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