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Closer examination of the 80 nucleotides starting at +59, which spans the cluster of minima, reveals a balanced G/C-rich composition of 36G 36C 4A 4U, in keeping with an intrinsic bias towards formation of stable secondary structure in this region.
Assuming that splenic B cells are representative of the whole B cell response and that B cell specificity does not bias hybrid formation, then splenic hybridoma frequency should reflect immunogenicity.
Alternatively, however, it is possible that the genomic sequence could influence different epigenetic domains and that primary DNA sequence itself could thus bias their formation and/or maintenance on a genome-wide basis.
Knowledge of the kinetic mechanism and the kinetic parameters for LRRK2, coupled with mechanistic simulations, enabled determination of initial concentrations of ATP and PLK-peptide substrate which would bias toward formation of the enzyme ATP complex.
Our design shows that certain non-seed miR nucleotides, such as 14, 18, 13, 11, and 17, are characterized by a strong bias towards formation of Watson-Crick pairing.
Because we did not detect a major peak that could be assigned to K27-linked Ub dimers as suggested by Ashida et al., we sought to test whether the use of UbK0 and Ub-D77 could bias chain formation with IpaH9.8.
There is no direct correlation between the number of bands detected by DGGE and the number of species present in a sample since numerous factors affect band number including sampling, PCR and differential DNA extraction biases, heteroduplex formation and divergence within multicopy number rDNA families.
Higher capacitance at near zero bias corroborates the formation of InN at AlGaN/InGaN due to larger band offset.
