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The genocide finding is likely to have an impact well beyond this trial.
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Median survival was calculated from the start of study drug (cycle 1, day 1) to time of death or last contact if alive; as noted in Results and Discussion, this differs from standard OS reported in clinical trials, as our analysis included time of survival beyond enrollment on this trial.
In addition the challenges faced by both participants and healthcare staff that were identified in these interviews appear to have 'relevance' [ 25] to trials of complex healthcare interventions beyond this particular trial in this particular setting.
However, root-system development beyond the term of this trial and its limitation to only one site and soil type, precludes more definitive statements on the widespread use of the trialled species for erosion control across New Zealand.
However, this goes beyond the purpose of this trial and may be the object of further studies.
However, a detailed analysis of factors contributing to these findings is beyond the scope of this trial.
Assessing adequacy of antimicrobial therapy was not part of the study hypothesis and would have been beyond the scope of this trial.
A concurrent design would have meant implementing a HDSS in another district that would have required funds far beyond the funding for this trial.
It was beyond the scope of this trial to assess all the indirect and direct costs related to home and clinic care.
Although measuring long-term outcomes was beyond the scope of this trial, the included CDPS actions were specifically selected because the evidence base was already strong that they lead to improved long-term outcomes.
Long-term epidemiologic follow-up of this trial beyond the randomised phase demonstrated 'legacy benefits', in which cardiovascular benefits persisted in patients previously randomised to metformin despite the cessation of randomised treatment and rapid equalisation of mean HbA1c between patients previously in the metformin and control arms of the study [ 52].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com