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However, beyond this cutpoint the measures diverged.
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The PSA cutpoint of 4 ng/ml was sensitive but relatively non-specific and likelihood ratios for this cutpoint demonstrated only moderate probability revisions.
This cutpoint is clinically applicable and prognostic with two specific antibodies.
This cutpoint was then applied to the two validation cohorts (Cohorts 2 and 3).
The actual test was not given when practice session performance was below this cutpoint.
Applying this cutpoint to the BHPS dataset would identify only 8.3% of the individuals as cases.
This cutpoint has been shown to be consistent with a diagnosis of moderate or severe dementia [ 28].
An optimal cutpoint was determined using the X-tile software for disease-specific survival in Cohort 1 and this cutpoint was then applied to the other two cohorts after median normalisation of AQUA scores.
A score of 29 or above has been found to optimally discriminate youth with MDE from those who do not meet criteria for this diagnosis [ 32] (participants meeting, and not meeting, this cutpoint are subsequently referred to as 'meeting MDE cutpoint' and 'not meeting MDE cutpoint' respectively).
This cutpoint showed that decreased levels of miR34 was associated with worse outcome (log-rank P=0.0024 and 0.0445, respectively).
This cutpoint was determined by standard clinical laboratory comparison methods and verification of the reference interval [ 26- 30].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com