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This persistence of spatial memory is well beyond the time window given for reorientation (Fig. 3.e4) in our study.
Importantly, this late life protective effect was observed even if daf-2 RNAi was applied relatively late in life beyond the time window in which it could extend lifespan (Fig. 2C blue, Supporting Fig. S2 and (Dillin et al., 2002).
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Altering the time window yielded similar results.
Its use is limited to the first 3-4.5 hours after stroke onset due to an increased risk of complications beyond this time window such symptomatic hemorrhagic transformation (HT) [ 1].
Be aware of the time-window system.
Comparability with the group of patients treated beyond the 4.5 hour time window in the randomised controlled trials is limited because maximum time from onset to treatment in the trials was six hours, while in our database, almost 400 patients were treated beyond six hours after stroke onset.
17 23 24 This is probably because of the inclusion of patients aged over 80 or with pre-existing disability or beyond the 4.5 hour time window in the group who received thrombolysis.
In the cases delayed beyond the currently approved time window, rt-PA is not warranted since the potential risk would outweigh benefits [ 5].
Mechanical interventions in acute ischemic stroke promise to provide emergency physicians with tools to treat patients in whom conventional thrombolysis might be ineffective or contraindicated, including most patients with stroke who arrive at the emergency department beyond the 3-hour time window for intravenous tissue plasminogen activator.
We believe that especially because of the increased mortality in this group, patients beyond the 4.5 hour time window should be preferentially treated in clinical trials with the aim of improving patient selection for thrombolytic therapy.
Finally, the cohort of patients treated with thrombolytic therapy beyond the 4.5 hour time window is relatively small.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com