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Notable differences are to be expected, however, if different parameterizations of the AIF are extrapolated beyond the time range used in the fitting procedure.
When comparing model 1 and 3 (the true model), we can see that differences in predictions occur mostly beyond the time range previously measured.
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Strictly speaking, our dynamic liver scans only demonstrate that the performed parametrization of the AIF shape by an inverse power law and the stated value of the parameter b holds up to about 60 min p.i.. Beyond that time range, no direct proof for this specific (and invariant) shape exists.
In reporting the first major amputation in 1997 2007, as a rule for the first major amputation, a 10-year major amputation free period was used; only 0.8% of major amputations were detected beyond this time range.
Our modeling and simulations of the CsA mediated ROS production gives biologists insight into mechanisms of toxicity and provide quantitative estimates of toxicity beyond the time and dose range used in experiments.
As a consequence the studied materials are capable to supply electrical stimulations to cells in a biological environment well beyond the conventional time-range.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com