Sentence examples for beyond the lesion site from inspiring English sources

Here, we provided the first evidence that reactive astrocytes attract OECs migration by secreted TNF-α not only in vitro but also in damaged spinal cord, suggesting a mechanism for guiding OECs migration into glial scar, which is crucial for OECs-mediated axons regrowth beyond the lesion site.

Our analysis showed that in all 3 cases, the damage compromised both short- and long-range connections, suggesting that disconnection mechanisms occurred beyond the lesion site.

To this end, longitudinal optic nerve sections were stained with an anti-GAP43 antibody and regenerating axons were quantified at various distances beyond the lesion site.

Surprisingly, with AAV2.Stat3-ca stimulation, axons elongating beyond the lesion site displayed very irregular courses, including frequent U-turns, suggesting massive directionality and guidance problems.

In vivo, intravitreal application of IL-6 tRGCsformed RGCs into a regenerative state, enabling axon regeneration beyond the lesion site of the optic nerve.

Likewise, intravitreal application of IL-6 induced axon regeneration beyond the lesion site of the optic nerve to similar extent as CNTF.

Interestingly, they also showed the demonstration of regeneration of motor axons growing beyond into the lesion site, which indicates the lesion site-crossing phenomenon from rostral to caudal [ 97].

These results suggest that inflammation-related impairments in choroidal circulation extend beyond the lesion sites and contribute to the pathogenesis of PIC.

The subsequent loss of grey matter in and around the lesion site did not continue beyond 24 hours after injury, whereas there was a loss of white matter spreading out from the centre of the lesion site that continued for up to one week after injury.

Increasing evidence indicates that olfactory ensheathing cells (OECs) implanted into spinal cord are found to migrate into the lesion site and induce axons regeneration beyond glial scar and resumption of functions.

To assess monoaminergic innervation of the spinal cord caudal to the lesion, TH-immunopositive and 5-HT-transporter-immunopositive axons projecting beyond an arbitrarily selected border 250 µm caudal to the lesion site were counted in spaced serial parasagittal sections six weeks after injury.