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45 As beta cell function declines, intensified treatment beyond the initial monotherapy regimen is required.
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The relapse rate was higher for ACTH as compared to Vigabatrin (55.5% against 33.3%) when considering the initial monotherapy.
In the case of metformin failure, the only clinical trial meeting the inclusion criteria included 103 patients in whom glibenclamide was added to the initial monotherapy (metformin + glibenclamide) and 104 patients who continued metformin monotherapy (control group).
32 The 2 clinical trials selected for glibenclamide failure included 350 patients in whom metformin was added to the initial monotherapy (glibenclamide + metformin) and 341 patients who continued glibenclamide monotherapy (control group).
If combination is superior in this analysis, then the averaged mean HSBP between initial monotherapy and initial combination therapy at the end of phase 2 will be compared.
In the BeSt study, patients with initial monotherapy had significantly more HBL than patients on the initial combination therapy [ 24].
We test this hypothesis comparing initial monotherapy with dual therapy in the management of essential hypertension.
Study participants are randomised 1 1 to either initial combination or initial monotherapy using an Interactive Voice Recognition System located at the Robertson Centre for Biostatistics at Glasgow University.
Of the 192/417 patients (46%) with PP, 100 (52%) had been randomized to initial monotherapy and 92 (48%) to initial combination therapy.
Digoxin is commonly used as an initial monotherapy.
Successful use of intravenous immunoglobulin as initial monotherapy in Landau-Kleffner syndrome.
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