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Therefore, growth arrest signals may provide additional functions beyond cell cycle regulation for some cell cycle-related proteins.
Originally described as a cyclin-dependent kinase (cdk) inhibitor, p57KIP2 has since been shown to influence other cellular processes, beyond cell cycle regulation, including cell death and cell migration.
Additional lines of research have described multiple roles for RB family proteins in tumor initiation and progression, beyond cell cycle regulation and interactions with E2F transcription factors (Chinnam and Goodrich, 2011; Knudsen and Knudsen, 2008).
Research in the last decade has highlighted the complexity of regulatory networks that ensure proper cell cycle progression, and has also identified multiple cellular functions beyond cell cycle regulation for RB and its two family members, p107 and p130.
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Hence, we wished to determine whether it is the cell-cycle inhibitory function of Xic1 that is required for cardiac differentiation, or whether an additional function of Xic1 beyond cell-cycle regulation is required.
Recent studies also indicate that cell cycle-related proteins contribute to much broader events beyond the cell cycle regulation in the developing and adult brains (Fig. 7A).
Recently, studies have shown that proteins with additional cellular functions beyond DNA repair and cell cycle regulation may ameliorate the toxic effects of agents that cause DNA damage [ 5- 8].
These data suggest that the cell cycle regulator CDKN2D is involved in both cell cycle regulation and granulocytic differentiation.
Gene expression analysis demonstrated effects on cell cycle regulation.
Likewise, in mammalian systems, MELK is essential for organogenesis, stem cell proliferation, and cell cycle regulation.
In addition, transcripts associated with cell cycle regulation and cell death were also identified.
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