Sentence examples for beyond a threshold Bcl-2 from inspiring English sources

The model reveals that the time-scale for Bax activation as well as its cell-to-cell variability is significantly increased as the Bcl-2 level increases, especially beyond a threshold Bcl-2 level (~0.75 μM).

Expansion of the polyQ tract beyond a threshold of 37 glutamines leads to the formation of toxic nuclear aggregates.

Testosterone may have a negative impact on the immune system when beyond a threshold level [11], [12].

Beyond a threshold of 6 MPa, cell viability is inversely proportional to the applied stress [ 173].

We observed a statistically significant increase of risk of SCC with increasing sun exposure beyond a threshold of 70,000 cumulated hours of exposure in a lifetime.

Gaudet et al. showed by both mathematical modelling and experimental measurements that critical thresholds of Bcl-2 exist beyond which cells suddenly lose their capacity to undergo MOMP.

The higher the radium activity (and dose), beyond a threshold value of 2 MBq, the shorter the latent period [ 126].

Beyond discussing new Bcl-2 proteins, Seamus Martin (Trinity College, Ireland) described a novel role for the protein Noxa in regulating autophagic cell death in tumour cells with oncogenic Ras.

First, additional survival pathways beyond the key Bcl-2 family members may operate in breast CSCs.

The natural BH3 mimetic -gossypol has been described as a pan Bcl-2 inhibitor targeting Bcl-2, Bcl-xL, Mcl-1 and Bcl-w [ 5, 21].

2. Proteins that regulate cell-cycle progression (for example, cyclin D1) and the apoptotic threshold (for example, Bcl-2, Bcl-xL and Bfl-1).