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However, beyond a certain dose range a non-linearity generally sets in.
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However, the local effects of BTX-A plateau at a certain dose beyond which increased BTX-A administration does not add therapeutic benefit [29].
Apart from suggesting a reduced response rate at excessively high doses, the data could also be read as providing evidence that, beyond some limit, conversion from mass to a certain dose parameter is not correct any more.
The evidence supports putting someone on a certain dose of a statin".
In Mr. Soares's case, that means a certain dose of cynicism and irreverence.
"There is a certain dose of tolerance now," Ms. Pavich said.
The risk appears statistically significant at a certain dose, but like most adverse drug effects, the risk could well be distributed on a continuum with dose.
"Showing that 6 out of 10 got by with a certain dose doesn't help us," he said.
Parexel's literature had also warned what to do in case of a cytokine storm: apply a certain dose of a certain steroid.
A certain dose of singular, obsessive thinking will help.
"It's a social lubricant, so there's increased levels of relaxation, but every person is going to have a different threshold dose, beyond which it's going to suppress the central action of the brain," says Mulhall. "It's a central depressant, so it's going to have a negative effect at a certain dose on the brain centres that trigger erections.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com