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We know that the LD between two variants is symmetric (Σ T = Σ ).
Calls from the different tools were merged, using BEDTools [ 82], if the reciprocator overlap between two variants is ≥ 0.5.
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The correlation between the two variants is r which is approximated by 1 n X k T X c.
The main difference between these two variants is that the number of iterations is fixed for the former, whereas it depends on the respondent's answers in the latter.
> -wrap-foot> is is known that in the case where there exists no population structure, the correlation between the marginal statistics of two variants is the same as the correlation between the genotypes from which the statistics were computed.
Moreover, linkage disequilibrium between the two variants was not strong (D' = 0.687 and r = 0.009).
The linkage disequilibrium between the two variants was r of 0.86.
Another difference between these two variants was that mono-, di- and tri- methylated Lysine 4 were also only present in histone H3.2.
Variants A and B of β-lg have similar tertiary structure at neutral pH as the amino acids that differ between the two variants are located on a mobile surface loop and in the hydrophobic core (Sawyer and Kontopidis 2000; Qin et al. 1999).
Two variants were assigned between 10% and 50% probability of being associated with statin-mediated changes in LDLC (Table S1B): rs1431005 located on chromosome 4 (Posterior probability = 0.13, P = 1.8×10−7) and rs13390159 located on chromosome 2 (Posterior probability = 0.17, P = 2.1×10−7).
After adjustment for race/ethnicity, the genotype prevalence of two variants was significantly different between men and women rs2031920 (CYP2E1) and rs2243248 (IL4) (Web Appendix 8).
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