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The second drawback of the earlier GLM analysis seems to be that it cannot represent the association between two lagged-time courses due to delayed response, since delayed response implies lack of linear association between two time courses.
Investigating these systems under many different conditions, we found it difficult to decide how much of the differences between two time courses were due to normal variation between cell cultures and experimental settings and how much was pointing toward true differences in the cells' response dynamics.
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Our expectation in employing these two damage regimes was that we might find some degree of overlap between the two time courses, but that we might also be able to discern treatment-specific, as well as cochlea- and utricle-specific, changes in gene expression.
The gene shown in Fig. 1a has two time courses in which the phase of peak expression is similar between the time courses, and the resultant vector has large magnitude.
An artificial data set with four time courses was created.
Five time course (TC) datasets were provided.
Nine time course studies were used for the meta-analysis.
Comparing samples between two independent time courses is a known challenge in the field, and can be confounded by experimental factors such as culture conditions [ 26, 69, 70].
According to this schedule, patients were seemingly interviewed between two and three times during the <9 month course of the study.
For both groups of students, chemistry was cited between four and five times more often than the next courses, biology and math.
Consequently, they share between four and five times as many variants over the course of an experiment.
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