The interface between two subunits consists mainly of residues from the N-terminal helices α4 and strand β4 that interact with residues in the loop between strands β2 and β3.
Most of the interactions the three molecules are forming with the proteins are with the intersecting helices between the two subunits of the enzymes.
The rmsds between the two subunits of dhMtb-BirA are 0.887 Å for 198 Cα equivalent atoms as opposed to the rmsds of 0.578 Å for 208 Cα pairs of the hMtb-BirA subunits.
In order to further study the relationship between the two subunits of complex I and Sp1, Pearson's correlation was performed in all three brain regions the prefrontal cortex, the parieto-ocipital and the striatum as well as in lymphocytes of normal subjects and schizophrenic patients (Table 3).
The association between the two subunits of the heterodimeric Drosophila and mammalian Notch receptors appears to depend upon metal ions, by virtue of the fact that chelating agents release the extracellular portion of the receptor and can, in fact, activate downstream signaling [15].
We also verified the known interaction between the two subunits of AP-2, μ and o', in the BiFc system – see Figure 9. YN-LeEix2_CD, YC-AtEHD2 and all Adaptin proteins were examined for fluorescence with the complementary half of the YFP protein and the results were negative (Figures 4,8).
Co-evolution also occurs between the two subunits of ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) genomes [ 56].
Both V199 and K113 are in close proximity to the active site C109XXC112, while Q214 is facing the cleft formed between the two subunits of DsbG (Fig. 4A).
As seen in Table 1, the detailed analysis of the MD trajectory predicted that extra L196C/I301C mutations on E172-173 may introduce the desirable cross-subunit disulfide bonds between the two subunits of the E172-173 dimer.
Therefore it is possible that the RC-1, which is a cationic peptide, may inhibit the activity of dengue protease via direct interactions with the active site or by blocking the binding between the two subunits of the protease complex.
